Spirochetal bacteria are driver pathogens in many emerging infectious diseases and represent a significant unmet medical need.
Spirochetes are biologically sophisticated, invasive and technically difficult to detect, biopsy, culture, diagnose and treat. When left untreated or unresolved (>6mos), infections can lead to worsening symptoms, immune system malfunction, lasting microbiome changes, additional comorbidities or diseases and death. All of which lead to large, often immeasurable negative impacts on patients, families and the healthcare system.
Flightpath Biosciences is “Thinking Beyond the Infection™”, bridging scientific unknowns by interrogating disparate fields of biology, taking risks, innovating and deploying potentially orthogonal approaches to achieve desired outcomes. We are working with leading scientists, therapeutics and diagnostics experts across multiple scientific disciplines within several esteemed academic institutions and government agencies to create novel, targeted solutions.
Our Platform
Flightpath Biosciences uses advanced drug discovery tools to identify optimal therapeutic candidates and cutting-edge drug delivery technology to vastly improve drug targeting and safety, reduce negative impacts on the microbiome, speed the time-to-market and eliminate non-target antibiotic resistance risks.
In parallel, our data science and bioinformatics partners are working hard to understand host and microbiome genetics and transcriptomics to further define the impact of our drugs on the patient’s immune system, microbiome and overall health. We believe this will lead us to new data, novel discoveries and potentially new diagnostics and therapeutics.
Science Driven & Data Supported
Hygromycin-A
Hygromycin-A is a breakthrough, first-in-class selective antibiotic that inhibits bacterial ribosomal peptidyl transferase in spirochetes. Flightpath has generated impressive MIC / MBC data and demonstrated spirochete selectivity in vitro and established efficacy in animals versus standard-of-care broad spectrum antibiotic therapies in vivo. Based on the selective nature of the molecule the company has not seen evidence of toxicity at mulitiple ascending doses. We are now advancing the research across all known and accessible members of the spirochete family.
Targeted Delivery
Flightpath has conducted extensive high throughput screening of FDA-approved compounds, yielding two high-potential bactericidal drugs with promising efficacy that could be repurposed for treatment of Lyme and other diseases. The company has developed proprietary, oral delivery technologies and pathogen-specific injectable formulations to achieve optimal efficacy at potentially lower doses with improved safety profiles.
Microbiome Diagnostic Signatures
Patients with Post-Treatment Lyme Disease often have neurological, psychological and / or immune system difficulties related to untreated infection and long-term, broad-spectrum antibiotic use. Flightpath has developed early indicative data that the impacts of chronic spirochetal infections can be detected in the gut microbiome. We are working with partners to understand the disease and the related genetic and longitudinal therapeutic impacts on the host microbiome to develop the world’s first microbiome diagnostic signature for patients with suspected PTLD.
Microbiome Consortia
Flightpath and its collaborators are working to advance the first therapeutic microbiome consortium product for patients suffering from Post-Treatmen Lyme Disease.
species of bacterial spirochetes identified
of spirochetes are oral treponemes (57); only 10 have been cultured
homology amongst treponemes
new Lyme disease diagnoses in the US each year
65M adults in the US have periodontal disease
people have some form of endemic trepanematosis
people are living with Persistent Lyme Disease in the US
cases of adult and congenital syphilis; an unseen US epidemic
new diagnostic efforts underway to identify patients with Lyme
Spirochete-driven Disease
The Spirochetes are a deeply-branching phylum of bacteria initially delineated by their serpentine shape and periplasmic flagella. Their unusual cellular ultrastructure, motility mechanism, metabolic pathways, capacity for gene regulation and to modulate and evade the immune system make them a challenging opponent. Pathogenic spirochetes include the agents of Lyme disease, leptospirosis, syphilis, relapsing fever, periodontal disease, digital dermatitis, and intestinal spirochetosis that pose immense, and growing, global threats to human and animal health.