_For the past two decades, despite billions invested in innovative treatment modalities, progress has been modest across infectious diseases, infection-associated cancers, oral health, women’s health, and inflammatory conditions.
_At Flightpath Biosciences, we are dedicated to advancing the science of infection-driven disease and developing a platform designed to interrupt disease before it becomes irreversible. Our goal is to unlock new possibilities for addressing complex diseases and ultimately reshape how they are treated.
“Fusobacterium not only is present in high amounts in CRC tissue but also can travel from oral sources to seed the tumor. It exploits tumor-specific glycan codes to adhere and is a plausible driver of both tumorigenesis and chemoresistance.”
- Dr. Wendy S. Garrett (Harvard T.H. Chan School of Public Health)
“Every day, new clinical research is published demonstrating the connection between oral health and overall health. I’ve yet to hear of a study that doesn’t show how good oral health leads to less overall healthcare costs, less hospitalization, and better health outcomes.”
- Stephen E Thorne IV, CEO, PDS Health
"If left untreated, Lyme disease infection can advance to affect multiple systems, potentially leading to neurological symptoms, cardiac complications, and arthritis."
(NCBI StatPearls, 2024)
"Individuals with periodontitis have a 19% increased risk of cardiovascular disease (CVD), and this risk rises to 44% for those aged 65 years and older. Type 2 diabetics with severe periodontal disease have 3.2 times greater mortality risk compared with individuals with no or mild periodontitis. Periodontitis is related to maternal infection, preterm birth, low birth weight, and preeclampsia."
— Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim). 2017 Apr-Jun;11(2):72-80. PMID: 28539867; PMCID: PMC5426403.
Bacterial Vaginosis doubles the risk of many sexually transmitted infections including HIV and increases the risk of preterm birth in pregnant women, which is the second-leading cause of death in newborns.
— Wyss Institute, November 28th 2022
“AIEC isolates repeatedly emerged as pathobionts with the ability to colonize the inflamed gut mucosa, invade epithelial cells, and persist within macrophages in IBD patients, particularly those with Crohn’s disease.”
— Thomas Clavel (University of Freiburg, Germany) cited in reviews and Frontiers in Medicine
TARGET THE PATHOGEN. PROTECT THE MICROBIOME. CHANGE THE OUTCOME.
_Targeted Bacterial Deletion™ is our proprietary platform designed to address infection-driven complex disease.
_By selectively removing harmful gram-negative bacteria, without negatively impacting the surrounding microbiome, we aim to interrupt the progression of inflammation, immune activation, and tissue damage before it becomes irreversible. This precision approach offers a new path to transform outcomes in complex disease.
_Diseases with heavy gram (-) bacterial involvement
Fusobacterium nucleatum, commonly found in the oral cavity, is strongly implicated in promoting colorectal cancer and metastasis.
Adherent Invasive E. Coli (AIEC) acts as a disease-promoting pathobiont with direct roles in inflammation and tissue pathology.
P. gingivalis, F. nucleatum, Aggregatibacter and Treponemes are keystone oral pathogens that disrupt host immune responses, promote chronic inflammation, and induce dysbiosis leading to progressive periodontal tissue destruction and bone loss
Borrelia burgdorferi, the bacteria responsible for Lyme disease, can cause both acute and chronic symptoms that affect multiple organ systems.
The evidence for Fusobacterium as causal in endometriosis includes findings that 64% of women with endometriosis have Fusobacterium infiltration in their endometrium compared to less than 10% of controls
The primary bacteria driving bacterial vaginosis is Gardnerella vaginalis, which forms a biofilm facilitating colonization and related vaginal microbiome disruptions linked to increased risks for pelvic inflammatory disease, infertility, endometriosis and upper genital tract infections, contributing to chronic gynecologic morbidity. 50-80% of women experience recurrence within 6 to 12 months.
ADDRESSING KEY BACTERIAL DRIVERS ACROSS ORAL AND GASTROINTESTINAL DISEASES, CANCER AND WOMEN’S HEALTH
_Our pipeline is built around a single principle: that pathogenic bacteria are persistent drivers of inflammation, immune disruption, and tissue damage across a wide range of diseases. Targeted Bacterial Deletion precisely removes harmful bacteria while sparing the healthy microbiome. By applying this approach, we aim to drive better outcomes in areas where infection has been overlooked.
